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Study Information
Study Attribute Value
CEBS Accession Number: 002-01736-0001-0000-0
Chemical Name: Boric acid
CASRN: 10043-35-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 153962_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/16/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 450 0.432 9.00 26.0 -4.918
Dimethyl Sulfoxide 
0         
 50 1048 476 0.454 9.52 26.0 0.000
Test Chemical Boric acid 
5         
 50 1033 475 0.460 9.50 26.0 1.239 
16         
 50 1046 466 0.446 9.32 26.0 -1.914 
50         
 50 1042 472 0.453 9.44 26.0 -0.269 
160         
 35 725 315 0.434 9.00 26.0 -4.341 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1044 714 0.684 14.28 26.0 50.575
Mitomycin-C 
 0.01      
 50 1044 2531 2.424 50.62 26.0 433.760
Trend: -0.598        
Probability: 0.725        

Trial #: 2    Activation: No Activation    Date: 02/21/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1032 418 0.405 8.36 26.5 -8.866
Dimethyl Sulfoxide 
0         
 50 1035 460 0.444 9.20 26.5 0.000
Test Chemical Boric acid 
200         
 50 1026 387 0.377 7.74 26.5 -15.132 
300         
 50 1031 480 0.466 9.60 32.0 4.753 
300         
 0 0 0 0.000 0.00 26.5 N/A 
400         
 50 1037 483 0.466 9.66 32.0 4.797 
400         
 0 0 0 0.000 0.00 26.5 N/A 
500         
 0 0 0 0.000 0.00 26.5 N/A 
500         
 50 1034 503 0.486 10.06 32.0 9.454
Positive Control Mitomycin-C 
 0.001     
 50 1040 1278 1.229 25.56 26.5 176.490
Mitomycin-C 
 0.01      
 10 209 767 3.670 76.70 26.5 725.718
Trend: 2.942        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/16/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 405 0.389 8.10 26.5 0.000
Negative (Not Specified) 
0         
 50 1049 433 0.413 8.66 26.5 5.996
Test Chemical Boric acid 
50         
 50 1047 411 0.393 8.22 26.5 0.803 
160         
 50 1047 428 0.409 8.56 26.5 4.972 
500         
 50 1045 466 0.446 9.32 26.5 14.511 
1600         
 50 1043 438 0.420 8.76 26.5 7.837
Positive Control Cyclophosphamide 
 0.3       
 50 1043 490 0.470 9.80 26.5 20.640
Cyclophosphamide 
2         
 50 1043 1168 1.120 23.36 26.5 187.566
Trend: 1.820        
Probability: 0.034        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/27/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 432 0.415 8.64 26.0 -16.437
Dimethyl Sulfoxide 
0         
 50 1036 514 0.496 10.28 26.0 0.000
Test Chemical Boric acid 
250         
 50 1039 484 0.466 9.68 26.0 -6.108 
500         
 50 1045 483 0.462 9.66 26.0 -6.840 
1600         
 50 1043 490 0.470 9.80 26.0 -5.309 
2000         
 50 1042 488 0.468 9.76 26.0 -5.605
Positive Control Cyclophosphamide 
 0.3       
 50 1041 636 0.611 12.72 26.0 23.141
Cyclophosphamide 
2         
 10 210 312 1.486 31.20 26.0 199.455
Trend: -0.730        
Probability: 0.767