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Study Information
Study Attribute Value
CEBS Accession Number: 002-01739-0001-0000-3
Chemical Name: Bromobenzene
CASRN: 108-86-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 544069_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/16/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 411 0.392 8.22 26.0 0.000
Test Chemical Bromobenzene 
50         
 50 1049 448 0.427 8.96 26.0 8.899 
160         
 50 1049 469 0.447 9.38 26.0 14.003 
500         
 50 1041 580 0.557 11.60 28.0 42.068
Positive Control Triethylenemelamine 
 0.015     
 50 1048 1474 1.406 29.48 26.0 258.637
Trend: 5.501        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/16/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 478 0.458 9.56 26.0 0.000
Test Chemical Bromobenzene 
16         
 50 1051 475 0.452 9.50 26.0 -1.289 
50         
 50 1042 476 0.457 9.52 26.0 -0.227 
160         
 50 1045 474 0.454 9.48 26.0 -0.932
Positive Control Cyclophosphamide 
1         
 50 1039 1125 1.083 22.50 26.0 136.488
Trend: -0.085        
Probability: 0.534