Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01743-0058-0000-0 |
Chemical Name: | Bromodichloromethane |
CASRN: | 75-27-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 173442 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 88 | 103 | 59 | 22 | 33 |
94 | 112 | 106 | 38 | ||||
61 | 79 | 81 | 44 | ||||
65 | 107 | 54 | 28 | ||||
Test Chemical | Bromodichloromethane | 15.625 | 64 | 124 | 61 | 32 | 41 |
69 | 120 | 104 | 51 | ||||
31.25 | 72 | 108 | 103 | 48 | 45 | ||
83 | 119 | 107 | 43 | ||||
62.5 | 91 | 90 | 59 | 22 | 35 | ||
78 | 106 | 115 | 49 | ||||
125 | 81 | 91 | 110 | 45 | 44 | ||
91 | 71 | 117 | 43 | ||||
250 | 69 | 35 | 86 | 42 | 47 | ||
84 | 33 | 129 | 51 | ||||
500 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 36 | 18 | 358 | 328 | 444* |
24 | 7 | 409 | 560 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 110 | 98 | 85 | 26 | 26 |
111 | 100 | 76 | 23 | ||||
99 | 98 | 74 | 25 | ||||
109 | 103 | 101 | 31 | ||||
Test Chemical | Bromodichloromethane | 200 | 105 | 83 | 67 | 21 | 24 |
93 | 79 | 75 | 27 | ||||
250 | 72 | 61 | 65 | 30 | 27 | ||
96 | 59 | 67 | 23 | ||||
300 | 105# | 51 | 85.5 | 27 | |||
148r | 91 | 68 | 15 | ||||
350 | 52 | 33 | 43 | 27 | 30 | ||
91# | 28 | 87 | 32 | ||||
400 | 110 | 20 | 112 | 34 | 38 | ||
82 | 20 | 106 | 43 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 40 | 22 | 165 | 139 | 172* |
41 | 31 | 252 | 206 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 74 | 110 | 226 | 102 | 89 |
53 | 98 | 146 | 92 | ||||
70 | 98 | 148 | 71 | ||||
68 | 94 | 186 | 91 | ||||
Test Chemical | Bromodichloromethane | 180 | 63 | 69 | 299 | 159 | 148* |
59 | 67 | 242 | 136 | ||||
240 | 41 | 23 | 233 | 189 | 165* | ||
60 | 34 | 255 | 141 | ||||
300 | 60 | 29 | 247 | 138 | 210* | ||
46 | 15 | 391 | 283 | ||||
360 | 51 | 10 | 459 | 300 | 271* | ||
56 | 9 | 402 | 241 | ||||
420 | 39 | 4 | 755 | 651 | 798* | ||
31 | 4 | 865 | 945 | ||||
480 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 28 | 22 | 791 | 953 | 960* |
26 | 19 | 750 | 968 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 129r | 119 | 113 | 29 | 28 |
110 | 101 | 101 | 31 | ||||
111 | 89 | 91 | 27 | ||||
107 | 110 | 81 | 25 | ||||
Test Chemical | Bromodichloromethane | 180 | 101 | 56 | 107 | 35 | 40 |
101 | 40 | 133 | 44 | ||||
240 | 79 | 39 | 100 | 42 | |||
121r | 32 | 185 | 51 | ||||
300 | 95 | 36 | 135 | 47 | 47* | ||
112 | 26 | 156 | 46 | ||||
360 | 88 | 20 | 111 | 42 | 49* | ||
105 | 21 | 177 | 56 | ||||
420 | 92 | 9 | 219 | 80 | 76* | ||
99 | 10 | 216 | 73 | ||||
480 | |||||||
Positive Control | 3-Methylcholanthrene | 2.5 | 89 | 50 | 666 | 251 | 266* |
81 | 49 | 680 | 282 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination