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Study Information
Study Attribute Value
CEBS Accession Number: 002-01744-0001-0000-9
Chemical Name: Bromoethane (ethyl bromide)
CASRN: 74-96-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 496296_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 400 0.383 8.00 26.5 0.000
Test Chemical Bromoethane (ethyl bromide) 
100         
 50 1049 566 0.540 11.32 26.5 40.960 
300         
 50 1048 891 0.850 17.82 26.5 122.112 
1000         
 10 208 381 1.832 38.10 26.5 378.540
Positive Control Mitomycin-C 
 0.0015    
 50 1051 705 0.671 14.10 26.5 75.244
Mitomycin-C 
 0.01      
 10 209 348 1.665 34.80 26.5 335.000
Trend: 22.336        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/12/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 382 0.367 7.64 26.0 0.000
Test Chemical Bromoethane (ethyl bromide) 
300         
 50 1047 665 0.635 13.30 26.0 73.086 
500         
 50 1052 932 0.886 18.64 26.0 141.428 
1000         
 10 208 284 1.365 28.40 26.0 272.085
Positive Control Mitomycin-C 
 0.0015    
 50 1045 514 0.492 10.28 26.0 34.040
Mitomycin-C 
 0.01      
 10 210 260 1.238 26.00 26.0 237.397
Trend: 18.953        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 406 0.388 8.12 25.5 0.000
Test Chemical Bromoethane (ethyl bromide) 
100         
 50 1047 424 0.405 8.48 25.5 4.334 
300         
 50 1045 503 0.481 10.06 25.5 24.010 
1000         
 50 1049 574 0.547 11.48 25.5 40.975
Positive Control Cyclophosphamide 
 0.5       
 50 1049 778 0.742 15.56 25.5 91.078
Cyclophosphamide 
2.5       
 10 210 375 1.786 37.50 25.5 360.063
Trend: 5.937        
Probability: 0.000