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Study Information
Study Attribute Value
CEBS Accession Number: 002-01748-0001-0000-3
Chemical Name: Butanal oxime
CASRN: 110-69-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: A22486_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 01/20/1993    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Butanal oxime 
2000         
 200 12 0.060 5.5 2 0.010 1.0 10 0.050 5.0 0 0.000 0.0 
3000         
 200 13 0.065 5.5 0 0.000 0.0 13 0.065 5.5 0 0.000 0.0 
4000         
 200 11 0.055 5.0 1 0.005 0.5 10 0.050 4.5 0 0.000 0.0 
5000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 13 0.520 44.0 8 0.320 28.0 5 0.200 20.0 0 0.000 0.0
Trend: 1.857 -0.533 2.041  
Probability: 0.032 0.703 0.021  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/22/1992    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Butanal oxime 
109         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
234         
 200 5 0.025 2.5 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0 
503         
 50 38 0.760 40.0 4 0.080 6.0 33 0.660 32.0 1 0.020 2.0 
1081         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
2325         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 25 1.000 56.0 14 0.560 36.0 11 0.440 32.0 0 0.000 0.0
Trend: 8.291 2.915 7.632  
Probability: 0.000 0.002 0.000  


Trial #:2   Activation: No Activation    Date: 06/22/1992    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 0.5 0 0.000 0.0 2 0.010 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 4 0.020 0.5 0 0.000 0.0 4 0.020 0.5 0 0.000 0.0
Test Chemical: Butanal oxime 
1081         
 200 10 0.050 3.0 2 0.010 1.0 8 0.040 2.5 0 0.000 0.0 
2325         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
5000         
 200 9 0.045 4.5 1 0.005 0.5 8 0.040 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 16 0.640 32.0 3 0.120 12.0 13 0.520 28.0 0 0.000 0.0
Trend: 2.275 0.259 2.181  
Probability: 0.011 0.398 0.015