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Study Information
Study Attribute Value
CEBS Accession Number: 002-01750-0001-0000-6
Chemical Name: Butyl benzyl phthalate
CASRN: 85-68-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 833451_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/29/1981    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 480 0.459 9.60 26.0 0.000
Test Chemical Butyl benzyl phthalate 
 0.4       
 50 1047 549 0.524 10.98 26.0 14.157 
1.25      
 50 1046 568 0.543 11.36 26.0 18.220 
4         
 50 1046 566 0.541 11.32 26.0 17.804
Positive Control Triethylenemelamine 
 0.015     
 50 1045 1596 1.527 31.92 26.0 232.500
Trend: 2.651        
Probability: 0.004        

Trial #: 2    Activation: No Activation    Date: 11/05/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 460 0.441 9.20 26.0 0.000
Test Chemical Butyl benzyl phthalate 
 0.4       
 50 1046 481 0.460 9.62 26.0 4.265 
1.25      
 50 1052 469 0.446 9.38 26.0 1.084 
4         
 50 1048 405 0.386 8.10 26.0 -12.377 
12.5       
 25 523 219 0.419 8.76 26.0 -5.056 
12.5       
 25 519 230 0.443 9.20 28.0 0.482
Positive Control Triethylenemelamine 
 0.015     
 50 1048 1482 1.414 29.64 26.0 220.637
Trend: -1.505        
Probability: 0.934        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/29/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 420 0.403 8.40 26.0 0.000
Test Chemical Butyl benzyl phthalate 
125         
 50 1034 466 0.451 9.32 26.0 11.811 
400         
 50 1040 466 0.448 9.32 26.0 11.166 
1250         
 50 1039 410 0.395 8.20 26.0 -2.099
Positive Control Cyclophosphamide 
1         
 50 1036 1711 1.652 34.22 26.0 309.740
Trend: -0.300        
Probability: 0.618