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Study Information
Study Attribute Value
CEBS Accession Number: 002-01756-0001-0000-2
Chemical Name: Butylated hydroxytoluene
CASRN: 128-37-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 549686_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/08/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 417 0.398 8.34 26.0 0.000
Test Chemical Butylated hydroxytoluene 
1.6       
 50 1048 466 0.445 9.32 26.0 11.644 
5         
 50 1044 431 0.413 8.62 26.0 3.654 
16         
 50 1048 444 0.424 8.88 26.0 6.373
Positive Control Mitomycin-C 
 0.005     
 25 523 732 1.400 29.28 26.0 251.415
Trend: 0.497        
Probability: 0.310        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/08/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 460 0.439 9.20 26.0 0.000
Test Chemical Butylated hydroxytoluene 
1.6       
 50 1045 465 0.445 9.30 26.0 1.474 
5         
 50 1047 415 0.396 8.30 26.0 -9.610 
16         
 50 1048 456 0.435 9.12 26.0 -0.775
Positive Control Cyclophosphamide 
1         
 50 1048 1061 1.012 21.22 26.0 130.872
Trend: -0.643        
Probability: 0.740