Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01756-0001-0000-2
Chemical Name: Butylated hydroxytoluene
CASRN: 128-37-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 549686_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/08/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 417 0.398 8.34 26.0 0.000
Test Chemical Butylated hydroxytoluene 
1.6       
 50 1048 466 0.445 9.32 26.0 11.644 
5         
 50 1044 431 0.413 8.62 26.0 3.654 
16         
 50 1048 444 0.424 8.88 26.0 6.373
Positive Control Mitomycin-C 
 0.005     
 25 523 732 1.400 29.28 26.0 251.415
Trend: 0.497        
Probability: 0.310        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/08/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 460 0.439 9.20 26.0 0.000
Test Chemical Butylated hydroxytoluene 
1.6       
 50 1045 465 0.445 9.30 26.0 1.474 
5         
 50 1047 415 0.396 8.30 26.0 -9.610 
16         
 50 1048 456 0.435 9.12 26.0 -0.775
Positive Control Cyclophosphamide 
1         
 50 1048 1061 1.012 21.22 26.0 130.872
Trend: -0.643        
Probability: 0.740