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Study Information
Study Attribute Value
CEBS Accession Number: 002-01758-0001-0000-4
Chemical Name: Butyraldehyde
CASRN: 123-72-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 824310_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/13/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 485 0.469 9.70 25.7 0.000
Test Chemical Butyraldehyde 
9         
 50 1037 720 0.694 14.40 25.7 48.024 
30         
 50 1036 1566 1.512 31.32 25.7 222.263 
90         
 25 518 1422 2.745 56.88 29.0 485.260
Positive Control Mitomycin-C 
 0.005     
 25 521 711 1.365 28.44 25.7 190.945
Trend: 40.740        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/13/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 476 0.453 9.52 25.7 0.000
Test Chemical Butyraldehyde 
9         
 50 1045 445 0.426 8.90 25.7 -5.976 
30         
 50 1043 596 0.571 11.92 25.7 26.170 
90         
 50 1036 670 0.647 13.40 25.7 42.794
Positive Control Cyclophosphamide 
1.5       
 25 519 700 1.349 28.00 25.7 197.801
Trend: 7.255        
Probability: 0.000