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Study Information
Study Attribute Value
CEBS Accession Number: 002-01763-0001-0000-0
Chemical Name: C.I. Acid orange 10
CASRN: 1936-15-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 819169_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/20/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1008 402 0.399 8.04 25.5 0.000
Test Chemical C.I. Acid orange 10 
500         
 50 1015 418 0.412 8.36 25.5 3.263 
1670         
 50 1008 415 0.412 8.30 25.5 3.234 
5000         
 50 1011 430 0.425 8.60 25.5 6.648
Positive Control Mitomycin-C 
 0.001     
 50 1001 555 0.554 11.10 25.5 39.025
Mitomycin-C 
 0.01      
 5 103 154 1.495 30.80 25.5 274.902
Trend: 0.875        
Probability: 0.191        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/20/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1015 502 0.495 10.04 25.5 0.000
Test Chemical C.I. Acid orange 10 
167         
 50 1019 440 0.432 8.80 25.5 -12.695 
500         
 50 1025 447 0.436 8.94 25.5 -11.825 
1670         
 50 1027 471 0.459 9.42 25.5 -7.272 
5000         
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Cyclophosphamide 
 0.04      
 50 1011 644 0.637 12.88 25.5 28.794
Cyclophosphamide 
2         
 5 102 204 2.000 40.80 25.5 304.382
Trend: -1.068        
Probability: 0.857