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Study Information
Study Attribute Value
CEBS Accession Number: 002-01763-0002-0000-1
Chemical Name: C.I. Acid orange 10
CASRN: 1936-15-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 819169_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 11/26/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 3.0 1 0.005 1.0 4 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0
Test Chemical: C.I. Acid orange 10 
2500         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0 
3750         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
5000         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 32 0.160 14.0 20 0.100 10.0 12 0.060 5.0 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 8 0.320 32.0 5 0.200 20.0 3 0.120 12.0 0 0.000 0.0
Trend: 1.019 0.000 1.019  
Probability: 0.154 0.000 0.154  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/10/1985    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: C.I. Acid orange 10 
3000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
3500         
 200 19 0.095 8.0 13 0.065 6.0 6 0.030 3.0 0 0.000 0.0 
3750         
 200 18 0.090 8.0 2 0.010 1.0 16 0.080 7.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 25 0.125 10.0 8 0.040 4.0 17 0.085 6.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 17 0.680 36.0 8 0.320 20.0 9 0.360 24.0 0 0.000 0.0
Trend: 4.465 2.818 3.538  
Probability: 0.000 0.002 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 11/26/1985    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 1 0.005 1.0 3 0.015 2.0 0 0.000 0.0
Test Chemical: C.I. Acid orange 10 
500         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
1250         
 200 17 0.085 8.0 5 0.025 3.0 12 0.060 6.0 0 0.000 0.0 
2500         
 200 30 0.150 10.0 19 0.095 6.0 11 0.055 5.0 0 0.000 0.0 
3750         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 26 0.130 12.0 7 0.035 4.0 19 0.095 9.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 18 0.720 48.0 9 0.360 24.0 9 0.360 36.0 0 0.000 0.0
Trend: 3.969 3.209 2.178  
Probability: 0.000 0.001 0.015