| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01763-0012-0000-2 |
| Chemical Name: | C.I. Acid orange 10 |
| CASRN: | 1936-15-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 295893_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 09/04/86 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Phosphate Buffered Saline | 0 | 4 | 4.47 ± 0.194 | |
| Test Chemical | C.I. Acid orange 10 | 550 | 4 | 4.94 ± 0.531 | |
1100 | 4 | 4.47 ± 0.319 | |||
2200 | 4 | 5.75 ± 0.341 | |||
| Positive Control | Mitomycin-C | 0.5 | 4 | 6.72 ± 0.631 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 08/01/88 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Phosphate Buffered Saline | 0 | 4 | 4.25 ± 0.568 | |
| Test Chemical | C.I. Acid orange 10 | 1650 | 4 | 8.69 ± 0.848 | |
2200 | 4 | 7.18 ± 0.185 | |||
| Positive Control | Mitomycin-C | 1 | 4 | 6.76 ± 0.169 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed