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Study Information
Study Attribute Value
CEBS Accession Number: 002-01763-0012-0000-2
Chemical Name: C.I. Acid orange 10
CASRN: 1936-15-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 295893_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 09/04/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.47 ± 0.194
Test Chemical C.I. Acid orange 10 
550         
 4 4.94 ± 0.531
  
1100         
 4 4.47 ± 0.319
  
2200         
 4 5.75 ± 0.341
Positive Control Mitomycin-C 
 0.5       
 4 6.72 ± 0.631


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/01/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.25 ± 0.568
Test Chemical C.I. Acid orange 10 
1650         
 4 8.69 ± 0.848
  
2200         
 4 7.18 ± 0.185
Positive Control Mitomycin-C 
1         
 4 6.76 ± 0.169


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed