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Study Information
Study Attribute Value
CEBS Accession Number: 002-01763-0013-0000-3
Chemical Name: C.I. Acid orange 10
CASRN: 1936-15-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 295893_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/01/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1639
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
 0.5       
 8 13.75 ± 1.53 0.0000
Test Chemical C.I. Acid orange 10 
550         
 8 5.00 ± 0.65 0.0496
  
1100         
 8 2.50 ± 0.91 0.5875
  
2200         
 8 4.75 ± 1.51 0.0683
Vehicle Control No Stressor 
 0         
 8 2.75 ± 0.92 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/09/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.6195
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 8.25 ± 1.33 0.0000
Test Chemical C.I. Acid orange 10 
550         
 8 1.25 ± 0.53 0.6193
  
1100         
 8 1.00 ± 0.53 0.7378
  
2200         
 8 1.25 ± 0.53 0.6193
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.50 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed