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Study Information
Study Attribute Value
CEBS Accession Number: 002-01766-0001-0000-3
Chemical Name: C.I. Acid red 14
CASRN: 3567-69-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 831530_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/07/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 378 0.360 7.56 26.5 0.000
Test Chemical C.I. Acid red 14 
160         
 50 1046 366 0.350 7.32 26.5 -2.897 
300         
 50 1049 384 0.366 7.68 26.5 1.587 
500         
 50 1046 417 0.399 8.34 26.5 10.634
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 544 0.520 10.88 26.5 44.190
Mitomycin-C 
 0.005     
 10 209 264 1.263 26.40 26.5 250.543
Trend: 1.537        
Probability: 0.062        

Trial #: 2    Activation: No Activation    Date: 08/14/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 396 0.378 7.92 26.0 0.000
Test Chemical C.I. Acid red 14 
160         
 50 1050 414 0.394 8.28 26.0 4.446 
300         
 50 1048 533 0.509 10.66 26.0 34.724 
500         
 50 1049 555 0.529 11.10 26.0 40.152
Positive Control Mitomycin-C 
 0.001     
 50 1049 591 0.563 11.82 26.0 49.242
Mitomycin-C 
 0.005     
 10 210 285 1.357 28.50 26.0 259.506
Trend: 6.184        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/13/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1044 444 0.425 8.88 26.5 0.000
Test Chemical C.I. Acid red 14 
160         
 50 1044 389 0.373 7.78 26.5 -12.387 
500         
 50 1043 498 0.477 9.96 26.5 12.270 
1600         
 50 1047 438 0.418 8.76 26.5 -1.634 
5000         
 50 1040 495 0.476 9.90 26.5 11.915
Positive Control Cyclophosphamide 
 0.3       
 50 1045 574 0.549 11.48 26.5 29.156
Trend: 2.269        
Probability: 0.012        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/30/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 467 0.446 9.34 26.0 0.000
Test Chemical C.I. Acid red 14 
1600         
 50 1043 495 0.475 9.90 26.0 6.301 
3000         
 50 1044 467 0.447 9.34 26.0 0.192 
4000         
 50 1046 478 0.457 9.56 26.0 2.355 
5000         
 50 1042 458 0.440 9.16 26.0 -1.551
Positive Control Cyclophosphamide 
 0.3       
 50 1047 635 0.606 12.70 26.0 35.844
Cyclophosphamide 
 0.6       
 10 209 186 0.890 18.60 26.0 99.334
Trend: -0.479        
Probability: 0.684