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Study Information
Study Attribute Value
CEBS Accession Number: 002-01766-0002-0000-4
Chemical Name: C.I. Acid red 14
CASRN: 3567-69-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 831530_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 09/04/1985    Harvest Time: 22.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: C.I. Acid red 14 
1000         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
1600         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
3000         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
5000         
 77 3 0.039 4.0 0 0.000 0.0 3 0.039 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 100 52 0.520 35.0 20 0.200 17.0 22 0.220 21.0 10 0.100 1.0
Mitomycin-C 
 0.125     
 50 67 1.340 64.0 23 0.460 38.0 34 0.680 46.0 10 0.200 1.0
Trend: 1.490 0.140 1.609  
Probability: 0.068 0.444 0.054  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/31/1984    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: C.I. Acid red 14 
1000         
 100 6 0.060 5.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
1600         
 100 5 0.050 4.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0 
3000         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 42 0.420 35.0 23 0.230 22.0 18 0.180 17.0 1 0.010 1.0
Trend: -0.626 -0.772 -0.446  
Probability: 0.734 0.780 0.672  


Trial #:2   Activation: No Activation    Date: 10/31/1984    Harvest Time: 18 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: C.I. Acid red 14 
1000         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0 
1600         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
3000         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
5000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 46 0.460 39.0 25 0.250 22.0 21 0.210 20.0 0 0.000 0.0
Mitomycin-C 
1         
 50 46 0.920 64.0 23 0.460 40.0 21 0.420 36.0 2 0.040 2.0
Trend: -0.851 -1.479 -0.044  
Probability: 0.803 0.930 0.518