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Study Information
Study Attribute Value
CEBS Accession Number: 002-01766-0012-0000-5
Chemical Name: C.I. Acid red 14
CASRN: 3567-69-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 142045_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/13/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0213
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.25 ± 1.85 0.0000
Test Chemical C.I. Acid red 14 
450         
 8 2.50 ± 0.50 0.5000
  
900         
 8 3.75 ± 0.96 0.1548
  
1800         
 7 4.86 ± 1.44 0.0419
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.82 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/22/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.3106
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 7 29.14 ± 5.60 0.0000
Test Chemical C.I. Acid red 14 
450         
 8 1.50 ± 0.73 0.7862
  
900         
 8 1.75 ± 0.59 0.6994
  
1800         
 8 2.50 ± 1.18 0.4241
Vehicle Control No Stressor 
 0         
 7 2.29 ± 0.52 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/07/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1395
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 5.50 ± 1.35 0.0046
Test Chemical C.I. Acid red 14 
900         
 8 2.00 ± 0.65 0.5000
  
1350         
 8 3.00 ± 0.85 0.1825
  
1800         
 8 3.00 ± 1.20 0.1825
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.65 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed