Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01768-0001-0000-5 |
Chemical Name: | C.I. Acid yellow 73 (fluorescein sodium) |
CASRN: | 518-47-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 372823_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
No Activation | 2 | Weakly Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Medium | 0 | 50 | 1048 | 308 | 0.294 | 6.16 | 26.5 | 0.000 |
Test Chemical | C.I. Acid yellow 73 (fluorescein sodium) | 5.01 | 50 | 1044 | 317 | 0.304 | 6.34 | 26.5 | 3.316 |
15 | 50 | 1046 | 309 | 0.295 | 6.18 | 26.5 | 0.517 | ||
50.1 | 50 | 1048 | 441 | 0.421 | 8.82 | 30.5 | 43.182 | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1046 | 476 | 0.455 | 9.52 | 26.5 | 54.841 |
Mitomycin-C | 0.01 | 10 | 210 | 252 | 1.200 | 25.20 | 26.5 | 308.312 | |
Trend: | 4.766 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Medium | 0 | 50 | 1044 | 289 | 0.277 | 5.78 | 26.0 | 0.000 |
Test Chemical | C.I. Acid yellow 73 (fluorescein sodium) | 75 | 50 | 1047 | 318 | 0.304 | 6.36 | 26.0 | 9.719 |
99.8 | 50 | 1047 | 344 | 0.329 | 6.88 | 26.0 | 18.690 | ||
150 | 50 | 1044 | 396 | 0.379 | 7.92 | 30.0 | 37.024 | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1051 | 516 | 0.491 | 10.32 | 26.5 | 77.358 |
Mitomycin-C | 0.01 | 10 | 209 | 230 | 1.100 | 23.00 | 26.5 | 297.543 | |
Trend: | 4.267 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Medium | 0 | 50 | 1046 | 415 | 0.397 | 8.30 | 25.5 | 0.000 |
Test Chemical | C.I. Acid yellow 73 (fluorescein sodium) | 150 | 50 | 1050 | 506 | 0.482 | 10.12 | 25.5 | 21.463 |
501 | 50 | 1050 | 783 | 0.746 | 15.66 | 25.5 | 87.956 | ||
1500 | 50 | 1047 | 924 | 0.883 | 18.48 | 29.5 | 122.438 | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1048 | 795 | 0.759 | 15.90 | 25.5 | 91.201 |
Cyclophosphamide | 2.5 | 10 | 211 | 440 | 2.085 | 44.00 | 25.5 | 425.598 | |
Trend: | 15.758 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Medium | 0 | 50 | 1046 | 395 | 0.378 | 7.90 | 25.5 | 0.000 |
Test Chemical | C.I. Acid yellow 73 (fluorescein sodium) | 134 | 50 | 1055 | 813 | 0.771 | 16.26 | 25.5 | 104.067 |
267 | 50 | 1052 | 939 | 0.893 | 18.78 | 25.5 | 136.366 | ||
445 | 50 | 1039 | 1115 | 1.073 | 22.30 | 29.9 | 184.180 | ||
668 | 50 | 1044 | 1154 | 1.105 | 23.08 | 29.5 | 192.712 | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1046 | 1097 | 1.049 | 21.94 | 25.5 | 177.722 |
Cyclophosphamide | 2.5 | 10 | 209 | 684 | 3.273 | 68.40 | 25.5 | 766.651 | |
Trend: | 19.780 | ||||||||
Probability: | 0.000 |