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Study Information
Study Attribute Value
CEBS Accession Number: 002-01768-0002-0000-6
Chemical Name: C.I. Acid yellow 73 (fluorescein sodium)
CASRN: 518-47-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 372823_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/18/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: C.I. Acid yellow 73 (fluorescein sodium) 
49.9       
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
150         
 100 5 0.050 4.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0 
499         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 50 21 0.420 26.0 2 0.040 4.0 19 0.380 26.0 0 0.000 0.0
Trend: 1.366 0.420 1.314  
Probability: 0.086 0.337 0.094  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/11/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 2 0.020 1.0 0 0.000 0.0 2 0.020 1.0 0 0.000 0.0
Test Chemical: C.I. Acid yellow 73 (fluorescein sodium) 
500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1500         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
5000         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 20 0.400 30.0 8 0.160 16.0 12 0.240 16.0 0 0.000 0.0
Trend: 0.254 1.360 -0.651  
Probability: 0.400 0.087 0.743