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Study Information
Study Attribute Value
CEBS Accession Number: 002-01768-0007-0000-1
Chemical Name: C.I. Acid yellow 73 (fluorescein sodium)
CASRN: 518-47-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 342354_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/16/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.93 ± 0.233
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 4 7.78 ± 0.611
  
600         
 4 7.61 ± 0.404
  
1200         
 4 8.27 ± 1.258
Positive Control Mitomycin-C 
 0.5       
 4 10.01 ± 1.745


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/01/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.25 ± 0.568
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
900         
 4 9.18 ± 1.778
  
1200         
 4 7.70 ± 0.889
Positive Control Mitomycin-C 
1         
 4 6.76 ± 0.169


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed