COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01768-0008-0000-2
Chemical Name: C.I. Acid yellow 73 (fluorescein sodium)
CASRN: 518-47-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 342354_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/14/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.5780
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 8.00 ± 1.65 0.0000
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 8 2.75 ± 0.53 0.0340
  
600         
 8 4.50 ± 1.18 0.0012
  
1200         
 8 1.00 ± 0.38 0.5000
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/13/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.5704
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 22.00 ± 3.32 0.0000
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 8 1.25 ± 0.37 0.5000
  
600         
 8 2.25 ± 0.59 0.1404
  
1200         
 8 1.00 ± 0.38 0.6313
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/31/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1254
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 7.25 ± 1.64 0.0000
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 8 2.00 ± 0.76 0.0281
  
600         
 8 2.50 ± 0.73 0.0100
  
1200         
 8 1.75 ± 0.45 0.0469
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.50 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/03/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4238
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 4.75 ± 1.25 0.0000
Test Chemical C.I. Acid yellow 73 (fluorescein sodium) 
300         
 8 0.75 ± 0.37 0.1580
  
600         
 8 0.25 ± 0.25 0.5000
  
1200         
 8 0.50 ± 0.33 0.2815
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed