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Study Information
Study Attribute Value
CEBS Accession Number: 002-01771-0001-0000-9
Chemical Name: C.I. Basic red 9 monohydrochloride
CASRN: 569-61-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 365437_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/21/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 391 0.372 7.82 26.0 0.000
Test Chemical C.I. Basic red 9 monohydrochloride 
 0.16      
 50 1048 419 0.400 8.38 26.0 7.366 
 0.5       
 50 1049 421 0.401 8.42 26.0 7.775 
1.6       
 50 1048 489 0.467 9.78 26.0 25.303 
5         
 50 1050 439 0.418 8.78 26.0 12.276
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 524 0.500 10.48 26.0 34.143
Mitomycin-C 
 0.005     
 10 210 320 1.524 32.00 26.0 309.207
Trend: 2.531        
Probability: 0.006        

Trial #: 2    Activation: No Activation    Date: 07/19/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 397 0.384 7.94 26.0 0.000
Test Chemical C.I. Basic red 9 monohydrochloride 
 0.16      
 50 1032 462 0.448 9.24 26.0 16.598 
 0.5       
 50 1042 460 0.441 9.20 26.0 14.979 
1.6       
 50 1041 442 0.425 8.84 26.0 10.586 
5         
 50 1042 427 0.410 8.54 26.0 6.731
Positive Control Mitomycin-C 
 0.0E-4    
 50 1038 553 0.533 11.06 26.0 38.758
Mitomycin-C 
 0.005     
 10 210 312 1.486 31.20 26.0 286.959
Trend: 0.443        
Probability: 0.329        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/21/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 377 0.360 7.54 26.0 0.000
Test Chemical C.I. Basic red 9 monohydrochloride 
 0.5       
 50 1046 369 0.353 7.38 26.0 -2.028 
1.6       
 50 1054 384 0.364 7.68 26.0 1.180 
5         
 50 1050 404 0.385 8.08 26.0 6.856 
16         
 50 1047 409 0.391 8.18 26.0 8.488
Positive Control Cyclophosphamide 
 0.1       
 50 1048 543 0.518 10.86 26.0 43.894
Cyclophosphamide 
 0.6       
 10 210 218 1.038 21.80 26.0 188.299
Trend: 1.564        
Probability: 0.059