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Study Information
Study Attribute Value
CEBS Accession Number: 002-01771-0002-0000-0
Chemical Name: C.I. Basic red 9 monohydrochloride
CASRN: 569-61-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 724892_SCE
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Test Failure 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 06/14/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 543 0.520 10.86 25.5 0.000
Test Chemical C.I. Basic red 9 monohydrochloride 
 0.5       
 50 1027 531 0.517 10.62 25.5 -0.591 
1.67      
 50 1048 564 0.538 11.28 34.0 3.471 
5         
 50 1031 574 0.557 11.48 34.0 7.042 
16.7       
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1041 622 0.598 12.44 25.5 14.879
Mitomycin-C 
 0.01      
 5 102 208 2.039 41.60 25.5 292.070
Trend: 1.286        
Probability: 0.099        

Trial #: 2    Activation: No Activation    Date: 07/13/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 526 0.503 10.52 25.7 0.000
Test Chemical C.I. Basic red 9 monohydrochloride 
2.5       
 50 1050 536 0.510 10.72 25.7 1.513 
5         
 50 1053 588 0.558 11.76 34.5 11.044 
7.5       
 50 1045 597 0.571 11.94 34.5 13.607 
10         
 0 0 0 0.000 0.00 34.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 656 0.627 13.12 25.7 24.715
Mitomycin-C 
 0.01      
 5 104 235 2.260 47.00 25.7 349.346
Trend: 2.560        
Probability: 0.005        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/14/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 472 0.450 9.44 25.5 0.000
Test Chemical C.I. Basic red 9 monohydrochloride 
1.67      
 50 1032 459 0.445 9.18 25.5 -1.058 
5         
 50 1046 471 0.450 9.42 25.5 0.170 
16.7       
 50 1042 601 0.577 12.02 34.0 28.308 
50         
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1046 712 0.681 14.24 25.5 51.424
Cyclophosphamide 
2         
 5 104 227 2.183 45.40 25.5 385.557
Trend: 4.087        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/13/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 476 0.455 9.52 25.7 0.000
Test Chemical C.I. Basic red 9 monohydrochloride 
20         
 50 1042 565 0.542 11.30 34.5 19.153 
25         
 50 1048 627 0.598 12.54 34.5 31.471 
35         
 50 1048 661 0.631 13.22 34.5 38.601 
40         
 0 0 0 0.000 0.00 34.5 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1050 841 0.801 16.82 25.7 76.008
Cyclophosphamide 
2         
 5 106 239 2.255 47.80 25.7 395.469
Trend: 5.520        
Probability: 0.000