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Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01771-0002-0000-0 |
Chemical Name: | C.I. Basic red 9 monohydrochloride |
CASRN: | 569-61-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 724892_SCE |
Study Result: | Not a Valid Test |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Test Failure |
No Activation | 2 | Test Failure |
Induced Rat Liver S9 | 1_S9 | Test Failure |
Induced Rat Liver S9 | 2_S9 | Test Failure |
Dose µg/mL |
Number Cells Examined |
Number Chromosomes Examined |
Total Number SCEs |
SCE / Chromosome |
SCE / Cell |
Hours in BRDU |
% Increase Over Solvent Control |
||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 |
50 | 1044 | 543 | 0.520 | 10.86 | 25.5 | 0.000 |
Test Chemical | C.I. Basic red 9 monohydrochloride | 0.5 |
50 | 1027 | 531 | 0.517 | 10.62 | 25.5 | -0.591 |
1.67 |
50 | 1048 | 564 | 0.538 | 11.28 | 34.0 | 3.471 | ||
5 |
50 | 1031 | 574 | 0.557 | 11.48 | 34.0 | 7.042 | ||
16.7 |
0 | 0 | 0 | 0.000 | 0.00 | 34.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 |
50 | 1041 | 622 | 0.598 | 12.44 | 25.5 | 14.879 |
Mitomycin-C | 0.01 |
5 | 102 | 208 | 2.039 | 41.60 | 25.5 | 292.070 | |
Trend: | 1.286 | ||||||||
Probability: | 0.099 |
Dose µg/mL |
Number Cells Examined |
Number Chromosomes Examined |
Total Number SCEs |
SCE / Chromosome |
SCE / Cell |
Hours in BRDU |
% Increase Over Solvent Control |
||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 |
50 | 1046 | 526 | 0.503 | 10.52 | 25.7 | 0.000 |
Test Chemical | C.I. Basic red 9 monohydrochloride | 2.5 |
50 | 1050 | 536 | 0.510 | 10.72 | 25.7 | 1.513 |
5 |
50 | 1053 | 588 | 0.558 | 11.76 | 34.5 | 11.044 | ||
7.5 |
50 | 1045 | 597 | 0.571 | 11.94 | 34.5 | 13.607 | ||
10 |
0 | 0 | 0 | 0.000 | 0.00 | 34.5 | N/A | ||
Positive Control | Mitomycin-C | 0.001 |
50 | 1046 | 656 | 0.627 | 13.12 | 25.7 | 24.715 |
Mitomycin-C | 0.01 |
5 | 104 | 235 | 2.260 | 47.00 | 25.7 | 349.346 | |
Trend: | 2.560 | ||||||||
Probability: | 0.005 |
Dose µg/mL |
Number Cells Examined |
Number Chromosomes Examined |
Total Number SCEs |
SCE / Chromosome |
SCE / Cell |
Hours in BRDU |
% Increase Over Solvent Control |
||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 |
50 | 1050 | 472 | 0.450 | 9.44 | 25.5 | 0.000 |
Test Chemical | C.I. Basic red 9 monohydrochloride | 1.67 |
50 | 1032 | 459 | 0.445 | 9.18 | 25.5 | -1.058 |
5 |
50 | 1046 | 471 | 0.450 | 9.42 | 25.5 | 0.170 | ||
16.7 |
50 | 1042 | 601 | 0.577 | 12.02 | 34.0 | 28.308 | ||
50 |
0 | 0 | 0 | 0.000 | 0.00 | 34.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.3 |
50 | 1046 | 712 | 0.681 | 14.24 | 25.5 | 51.424 |
Cyclophosphamide | 2 |
5 | 104 | 227 | 2.183 | 45.40 | 25.5 | 385.557 | |
Trend: | 4.087 | ||||||||
Probability: | 0.000 |
Dose µg/mL |
Number Cells Examined |
Number Chromosomes Examined |
Total Number SCEs |
SCE / Chromosome |
SCE / Cell |
Hours in BRDU |
% Increase Over Solvent Control |
||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 |
50 | 1046 | 476 | 0.455 | 9.52 | 25.7 | 0.000 |
Test Chemical | C.I. Basic red 9 monohydrochloride | 20 |
50 | 1042 | 565 | 0.542 | 11.30 | 34.5 | 19.153 |
25 |
50 | 1048 | 627 | 0.598 | 12.54 | 34.5 | 31.471 | ||
35 |
50 | 1048 | 661 | 0.631 | 13.22 | 34.5 | 38.601 | ||
40 |
0 | 0 | 0 | 0.000 | 0.00 | 34.5 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 |
50 | 1050 | 841 | 0.801 | 16.82 | 25.7 | 76.008 |
Cyclophosphamide | 2 |
5 | 106 | 239 | 2.255 | 47.80 | 25.7 | 395.469 | |
Trend: | 5.520 | ||||||||
Probability: | 0.000 |