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Study Information
Study Attribute Value
CEBS Accession Number: 002-01774-0002-0000-3
Chemical Name: C.I. Direct black 38
CASRN: 1937-37-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 325575_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/25/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: C.I. Direct black 38 
160         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
300         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
500         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 53 0.265 23.5 22 0.110 10.5 31 0.155 14.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 22 0.440 36.0 7 0.140 14.0 15 0.300 28.0 0 0.000 0.0
Trend: -1.376 0.000 -1.376  
Probability: 0.916 0.000 0.916  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/25/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: C.I. Direct black 38 
160         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0 
300         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
500         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 43 0.215 19.0 12 0.060 5.0 31 0.155 14.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 26 0.520 48.0 11 0.220 20.0 15 0.300 30.0 0 0.000 0.0
Trend: 0.032 0.000 0.032  
Probability: 0.487 0.000 0.487