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Study Information
Study Attribute Value
CEBS Accession Number: 002-01774-0002-0000-3
Chemical Name: C.I. Direct black 38
CASRN: 1937-37-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 325575_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/25/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Medium
0         
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: C.I. Direct black 38
160         
200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
300         
200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
500         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C
 0.0625    
200 53 0.265 23.5 22 0.110 10.5 31 0.155 14.0 0 0.000 0.0
Mitomycin-C
 0.25      
50 22 0.440 36.0 7 0.140 14.0 15 0.300 28.0 0 0.000 0.0
Trend: -1.376 0.000 -1.376  
Probability: 0.916 0.000 0.916  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/25/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Medium
0         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: C.I. Direct black 38
160         
200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0
300         
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
500         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide
2.5       
200 43 0.215 19.0 12 0.060 5.0 31 0.155 14.5 0 0.000 0.0
Cyclophosphamide
7.5       
50 26 0.520 48.0 11 0.220 20.0 15 0.300 30.0 0 0.000 0.0
Trend: 0.032 0.000 0.032  
Probability: 0.487 0.000 0.487