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Study Information
Study Attribute Value
CEBS Accession Number: 002-01784-0001-0000-3
Chemical Name: C.I. Direct blue 6
CASRN: 2602-46-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 160428_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/13/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 490 0.467 9.80 26.0 0.000
Test Chemical C.I. Direct blue 6 
10         
 50 1048 441 0.421 8.82 26.0 -9.914 
30         
 50 1048 484 0.462 9.68 26.0 -1.130 
100         
 50 1047 485 0.463 9.70 26.0 -0.831
Positive Control Mitomycin-C 
 0.005     
 25 524 600 1.145 24.00 26.0 145.132
Trend: 0.308        
Probability: 0.379        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/13/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1048 431 0.411 8.62 26.0 0.000
Test Chemical C.I. Direct blue 6 
30         
 50 1048 429 0.409 8.58 26.0 -0.464 
100         
 50 1051 481 0.458 9.62 26.0 11.282 
300         
 50 1049 477 0.455 9.54 26.0 10.567
Positive Control Cyclophosphamide 
1         
 25 522 586 1.123 23.44 26.0 172.968
Trend: 1.981        
Probability: 0.024