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Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01787-0006-0000-1 |
Chemical Name: | C.I. Direct brown 95 |
CASRN: | 16071-86-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 162126 |
Study Result: | Positive |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
96 | 105 | 50 | 17 | 20 |
97 | 96 | 55 | 19 | ||||
102 | 116 | 64 | 21 | ||||
88 | 83 | 60 | 23 | ||||
Test Chemical | C.I. Direct brown 95 |
125 |
86 | 117 | 41 | 16 | 18 |
73# | 83 | 43.5 | 20 | ||||
250 |
72 | 112 | 42 | 19 | 18 | ||
66 | 100 | 33 | 17 | ||||
93 | 114 | 46 | 16 | ||||
500 |
56 | 59 | 36 | 21 | 21 | ||
58 | 72 | 49 | 28 | ||||
64 | 72 | 25 | 13 | ||||
1000 |
76 | 44 | 59 | 26 | 24 | ||
75 | 52 | 52 | 23 | ||||
62 | 49 | 44 | 24 | ||||
2000 |
84 | 11 | 54 | 21 | 26 | ||
62 | 4 | 53 | 28 | ||||
50 | 5 | 41 | 28 | ||||
3000 |
88 | 44 | 61 | 23 | 28 | ||
70 | 42 | 77 | 36 | ||||
91 | 40 | 70 | 26 | ||||
5000 |
|||||||
Positive Control | Ethyl Methane Sulfonate |
250 |
62 | 49 | 671 | 363 | 523* |
63 | 35 | 907 | 479 | ||||
40 | 22 | 867 | 729 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
51# | 78 | 162 | 105 | 104 |
54 | 96 | 164 | 102 | ||||
49r | 90 | 116 | 79 | ||||
56 | 126 | 173 | 104 | ||||
Test Chemical | C.I. Direct brown 95 |
31.3 |
55 | 105 | 102 | 62 | 54 |
45# | 103 | 67 | 49 | ||||
62 | 102 | 97 | 52 | ||||
62.5 |
55 | 122 | 81 | 50 | 39 | ||
56# | 120 | 48 | 29 | ||||
125 |
67 | 125 | 95 | 47 | 58 | ||
53 | 123 | 96 | 60 | ||||
49# | 99 | 97 | 66 | ||||
250 |
59 | 86 | 110 | 63 | 71 | ||
38 | 68 | 102 | 89 | ||||
39 | 90 | 71 | 61 | ||||
500 |
56 | 84 | 142 | 85 | 69 | ||
49 | 96 | 116 | 78 | ||||
70# | 115 | 90 | 43 | ||||
1000 |
39 | 54 | 95 | 81 | 92 | ||
47# | 62 | 158 | 113 | ||||
45 | 62 | 111 | 83 | ||||
Positive Control | Ethyl Methane Sulfonate |
250 |
31 | 22 | 779 | 833 | 830* |
35 | 22 | 865 | 828 | ||||
10r | 5 | 421.5 | 1453 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
50# | 79 | 100 | 67 | 67 |
52 | 96 | 102 | 65 | ||||
45r | 86 | 78 | 57 | ||||
53 | 125 | 111 | 69 | ||||
Test Chemical | C.I. Direct brown 95 |
31.3 |
61 | 102 | 74 | 41 | 40 |
44# | 104 | 45 | 34 | ||||
54 | 106 | 74 | 46 | ||||
62.5 |
55# | 121 | 39 | 24 | 29 | ||
54 | 124 | 55 | 34 | ||||
125 |
47# | 98 | 66 | 47 | 43 | ||
52 | 124 | 77 | 50 | ||||
65 | 126 | 62 | 32 | ||||
250 |
38 | 91 | 51 | 45 | 50 | ||
58 | 88 | 80 | 46 | ||||
37 | 67 | 66 | 60 | ||||
500 |
54 | 85 | 110 | 68 | 47 | ||
48 | 97 | 64 | 44 | ||||
69# | 117 | 62 | 30 | ||||
1000 |
47# | 64 | 104 | 75 | 64 | ||
43 | 61 | 82 | 64 | ||||
41 | 58 | 64 | 53 | ||||
Positive Control | Ethyl Methane Sulfonate |
250 |
33 | 22 | 661 | 674 | 685* |
29 | 22 | 609 | 696 | ||||
8r | 4 | 345 | 1500 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
123r | 121 | 130.5 | 35 | 34 |
117 | 103 | 94 | 27 | ||||
110 | 97 | 125 | 38 | ||||
92 | 100 | 99 | 36 | ||||
Test Chemical | C.I. Direct brown 95 |
15.6 |
107 | 66 | 149 | 46 | 56* |
99# | 63 | 162 | 55 | ||||
81 | 70 | 161 | 66 | ||||
31.3 |
89 | 61 | 223 | 84 | 68* | ||
90 | 74 | 179 | 66 | ||||
112 | 76 | 177 | 53 | ||||
62.5 |
82 | 59 | 181 | 73 | 84* | ||
96 | 63 | 215 | 74 | ||||
79 | 57 | 247 | 105 | ||||
125 |
89 | 58 | 242 | 90 | 99* | ||
101 | 53 | 307 | 101 | ||||
99 | 64 | 309 | 104 | ||||
250 |
91 | 56 | 168 | 62 | 68* | ||
94# | 53 | 242 | 86 | ||||
93 | 59 | 153 | 55 | ||||
500 |
126r | 26 | 234 | 62 | 94* | ||
96 | 30 | 247 | 85 | ||||
103# | 19 | 315 | 102 | ||||
1000 |
|||||||
Positive Control | 3-Methylcholanthrene |
2.5 |
92 | 47 | 682 | 248 | 237* |
97 | 47 | 620 | 214 | ||||
92 | 55 | 689 | 250 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water |
0 |
72 | 102 | 82 | 38 | 38 |
78 | 110 | 86 | 37 | ||||
67 | 97 | 77 | 38 | ||||
62 | 91 | 73 | 39 | ||||
Test Chemical | C.I. Direct brown 95 |
50 |
54 | 50 | 144 | 89 | 88* |
48 | 47 | 135 | 94 | ||||
60 | 57 | 148 | 82 | ||||
100 |
62# | 55 | 142 | 76 | 68* | ||
67 | 75 | 119 | 60 | ||||
71 | 60 | 145 | 69 | ||||
200 |
56 | 41 | 107 | 64 | 54 | ||
66 | 24 | 105 | 53 | ||||
68 | 41 | 94 | 46 | ||||
300 |
64 | 22 | 168 | 87 | 76* | ||
69 | 11 | 155 | 75 | ||||
68 | 19 | 134 | 66 | ||||
400 |
84* | ||||||
58 | 29 | 100 | 58 | ||||
54 | 4 | 181 | 111 | ||||
500 |
61 | 7 | 121 | 66 | |||
700 |
|||||||
Positive Control | 3-Methylcholanthrene |
2.5 |
66 | 63 | 432 | 217 | 212* |
62# | 60 | 383 | 208 |