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Study Information
Study Attribute Value
CEBS Accession Number: 002-01793-0001-0000-3
Chemical Name: C.I. Disperse blue 1
CASRN: 2475-45-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 776658_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 06/04/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1041 366 0.352 7.32 25.5 0.000
Test Chemical C.I. Disperse blue 1 
 0.33      
 50 1019 305 0.299 6.10 25.5 -14.868 
1         
 50 1018 352 0.346 7.04 25.5 -1.652 
3.3       
 50 1004 447 0.445 8.94 25.5 26.632 
10         
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1038 799 0.770 15.98 25.5 118.937
Mitomycin-C 
 0.01      
 5 104 194 1.865 38.80 25.5 430.564
Trend: 3.889        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 25 525 189 0.360 7.56 25.5 0.000
Test Chemical C.I. Disperse blue 1 
3.3       
 25 525 156 0.297 6.24 25.5 -17.460 
7.5       
 25 524 239 0.456 9.56 25.5 26.696 
10         
 25 523 268 0.512 10.72 25.5 42.341
Positive Control Mitomycin-C 
 0.001     
 25 522 279 0.534 11.16 25.5 48.467
Mitomycin-C 
 0.01      
 5 104 187 1.798 37.40 25.5 399.466
Trend: 5.013        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/04/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1043 346 0.332 6.92 25.5 0.000
Test Chemical C.I. Disperse blue 1 
1         
 50 1049 395 0.377 7.90 25.5 13.509 
3.3       
 50 1046 406 0.388 8.12 25.5 17.004 
10         
 50 1046 483 0.462 9.66 25.5 39.195
Positive Control Cyclophosphamide 
 0.4       
 50 1045 611 0.585 12.22 25.5 76.252
Cyclophosphamide 
2         
 5 104 115 1.106 23.00 25.5 233.329
Trend: 4.632        
Probability: 0.000