Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01795-0001-0000-5 |
Chemical Name: | C.I. Disperse red 60 |
CASRN: | 17418-58-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 448988_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1028 | 433 | 0.421 | 8.66 | 26.0 | 0.000 |
Test Chemical | C.I. Disperse red 60 | 5 | 50 | 1038 | 441 | 0.425 | 8.82 | 26.0 | 0.866 |
16 | 50 | 1034 | 389 | 0.376 | 7.78 | 26.0 | -10.683 | ||
50 | 50 | 1027 | 393 | 0.383 | 7.86 | 26.0 | -9.149 | ||
100 | 50 | 1033 | 487 | 0.471 | 9.74 | 26.0 | 11.927 | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1030 | 554 | 0.538 | 11.08 | 26.0 | 27.696 |
Mitomycin-C | 0.005 | 10 | 208 | 207 | 0.995 | 20.70 | 26.0 | 136.272 | |
Trend: | 0.643 | ||||||||
Probability: | 0.260 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1050 | 446 | 0.425 | 8.92 | 26.0 | 0.000 |
Test Chemical | C.I. Disperse red 60 | 5 | 50 | 1047 | 494 | 0.472 | 9.88 | 26.0 | 11.080 |
16 | 50 | 1049 | 451 | 0.430 | 9.02 | 26.0 | 1.217 | ||
50 | 50 | 1048 | 482 | 0.460 | 9.64 | 26.0 | 8.278 | ||
100 | 50 | 1050 | 475 | 0.452 | 9.50 | 26.0 | 6.502 | ||
Positive Control | Cyclophosphamide | 0.1 | 50 | 1050 | 556 | 0.530 | 11.12 | 26.0 | 24.664 |
Cyclophosphamide | 0.6 | 10 | 210 | 220 | 1.048 | 22.00 | 26.0 | 146.637 | |
Trend: | 0.654 | ||||||||
Probability: | 0.256 |