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Study Information
Study Attribute Value
CEBS Accession Number: 002-01796-0002-0000-7
Chemical Name: C.I. Disperse yellow 3
CASRN: 2832-40-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 041446_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/12/1985    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 3 0.015 2.0 1 0.005 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: C.I. Disperse yellow 3 
150.9       
 200 4 0.020 2.0 0 0.000 0.0 2 0.010 1.0 2 0.010 1.0 
502.5       
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1000         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 37 0.185 14.0 20 0.100 8.0 17 0.085 8.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 19 0.760 48.0 7 0.280 28.0 12 0.480 36.0 0 0.000 0.0
Trend: -0.829 1.797 -1.876  
Probability: 0.796 0.036 0.970  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/12/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 1 0.005 1.0 1 0.005 1.0
Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: C.I. Disperse yellow 3 
996         
 200 6 0.030 3.0 1 0.005 1.0 5 0.025 3.0 0 0.000 0.0 
1200         
 200 5 0.025 3.0 1 0.005 1.0 4 0.020 2.0 0 0.000 0.0 
1500         
 200 5 0.025 2.0 2 0.010 1.0 3 0.015 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 29 0.145 12.0 15 0.075 7.0 14 0.070 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 14 0.560 36.0 7 0.280 24.0 7 0.280 24.0 0 0.000 0.0
Trend: -0.594 0.000 -0.205  
Probability: 0.724 0.500 0.581