Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01796-0012-0000-8
Chemical Name:	C.I. Disperse yellow 3
CASRN:	2832-40-8
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	221078_SCE
Study Result:	Positive

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	04/18/89	42	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 42 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	6.65 ± 0.403
Test Chemical	C.I. Disperse yellow 3	450	4	6.01 ± 0.530
		900	4	8.19 ± 0.518
		1800	4	9.13 ± 1.015
Positive Control	Dimethylbenzanthracene	2.5	4	16.69 ± 0.892

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	05/03/89	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	4.98 ± 0.509
Test Chemical	C.I. Disperse yellow 3	450	4	5.55 ± 0.434
		900	4	4.86 ± 0.288
		1800	4	7.37 ± 1.088
Positive Control	Dimethylbenzanthracene	2.5	4	9.91 ± 0.596

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed