COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01803-0001-0000-5
Chemical Name: C.I. Pigment red 3
CASRN: 2425-85-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 069775_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/22/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 401 0.382 8.02 26.0 0.000
Test Chemical C.I. Pigment red 3 
10         
 50 1049 416 0.397 8.32 26.0 3.840 
16         
 50 1051 436 0.415 8.72 26.0 8.625 
30         
 50 1048 420 0.401 8.40 26.0 4.938 
50         
 50 1048 422 0.403 8.44 26.0 5.438
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 495 0.472 9.90 26.0 23.559
Mitomycin-C 
 0.005     
 10 211 299 1.417 29.90 26.0 271.051
Trend: 0.708        
Probability: 0.240        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/22/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 444 0.424 8.88 26.0 0.000
Test Chemical C.I. Pigment red 3 
30         
 50 1049 461 0.439 9.22 26.0 3.730 
50         
 50 1049 448 0.427 8.96 26.0 0.805 
100         
 50 1052 471 0.448 9.42 26.0 5.678 
160         
 50 1051 451 0.429 9.02 26.0 1.287
Positive Control Cyclophosphamide 
 0.1       
 50 1049 610 0.582 12.20 26.0 37.256
Cyclophosphamide 
 0.6       
 10 210 325 1.548 32.50 26.0 265.294
Trend: 0.336        
Probability: 0.369