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Study Information
Study Attribute Value
CEBS Accession Number: 002-01803-0002-0000-6
Chemical Name: C.I. Pigment red 3
CASRN: 2425-85-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 069775_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/23/1986    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: C.I. Pigment red 3 
50         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
100         
 200 6 0.030 2.5 0 0.000 0.0 6 0.030 2.5 0 0.000 0.0 
160         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 52 0.260 22.0 25 0.125 10.5 27 0.135 12.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 21 0.420 34.0 11 0.220 20.0 10 0.200 18.0 0 0.000 0.0
Trend: -0.157 -0.679 0.134  
Probability: 0.562 0.752 0.447  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/21/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 50 6 0.120 3.0 0 0.000 0.0 6 0.120 3.0 0 0.000 0.0
Test Chemical: C.I. Pigment red 3 
50         
 50 6 0.120 3.0 2 0.040 1.0 4 0.080 2.0 0 0.000 0.0 
100         
 50 1 0.020 0.5 0 0.000 0.0 1 0.020 0.5 0 0.000 0.0 
160         
 50 4 0.080 2.0 0 0.000 0.0 4 0.080 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 25 0.125 12.0 6 0.030 3.0 19 0.095 9.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 200 12 0.060 20.0 6 0.030 10.0 6 0.030 10.0 0 0.000 0.0
Trend: -0.657 -0.340 -0.574  
Probability: 0.744 0.633 0.717