COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01812-0001-0000-5
Chemical Name: C.I. Solvent yellow 14
CASRN: 842-07-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 247659_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1049 402 0.383 8.04 25.3 0.000
Test Chemical C.I. Solvent yellow 14 
2.47      
 50 1019 454 0.446 9.08 25.3 16.260 
8.22      
 50 1027 509 0.496 10.18 32.5 29.329 
24.65      
 50 1042 581 0.558 11.62 32.5 45.498 
82.2       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1034 518 0.501 10.36 25.3 30.725
Mitomycin-C 
 0.01      
 5 106 225 2.123 45.00 25.3 453.893
Trend: 6.034        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/24/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 25 523 223 0.426 8.92 26.5 0.000
Test Chemical C.I. Solvent yellow 14 
40.2       
 25 521 224 0.430 8.96 33.5 0.834 
55.3       
 25 516 263 0.510 10.52 33.5 19.537 
70.6       
 25 517 294 0.569 11.76 33.5 33.369 
85         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1051 548 0.521 10.96 26.5 22.285
Mitomycin-C 
 0.01      
 5 105 197 1.876 39.40 26.5 340.021
Trend: 3.740        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/27/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1035 371 0.358 7.42 25.3 0.000
Test Chemical C.I. Solvent yellow 14 
24.65      
 50 1051 584 0.556 11.68 25.3 55.016 
82.2       
 50 1041 535 0.514 10.70 32.5 43.374 
246.5       
 50 1045 591 0.566 11.82 32.5 57.775
Positive Control Cyclophosphamide 
 0.4       
 50 1044 741 0.710 14.82 25.3 98.009
Cyclophosphamide 
2         
 5 105 205 1.952 41.00 25.3 444.667
Trend: 5.885        
Probability: 0.000