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Study Information
Study Attribute Value
CEBS Accession Number: 002-01812-0002-0000-6
Chemical Name: C.I. Solvent yellow 14
CASRN: 842-07-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 247659_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/27/1985    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 1.0 2 0.010 1.0 3 0.015 1.0 0 0.000 0.0
Acetone 
0         
 200 1 0.005 1.0 0 0.000 0.0 0 0.000 0.0 1 0.005 1.0
Test Chemical: C.I. Solvent yellow 14 
15.1       
 200 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
37.8       
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0 
75.5       
 200 5 0.025 2.0 2 0.010 1.0 3 0.015 1.0 0 0.000 0.0 
112.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 61 0.305 22.0 32 0.160 13.0 27 0.135 12.0 2 0.010 1.0
Mitomycin-C 
 0.08      
 25 16 0.640 44.0 6 0.240 20.0 10 0.400 32.0 0 0.000 0.0
Trend: 0.456 0.548 1.845  
Probability: 0.324 0.292 0.033  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/09/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 8 0.040 3.0 3 0.015 2.0 5 0.025 2.0 0 0.000 0.0
Acetone 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: C.I. Solvent yellow 14 
125         
 200 8 0.040 3.0 1 0.005 1.0 7 0.035 3.0 0 0.000 0.0 
185.5       
 200 5 0.025 2.0 1 0.005 1.0 4 0.020 2.0 0 0.000 0.0 
250         
 200 7 0.035 3.0 2 0.010 1.0 4 0.020 2.0 1 0.005 1.0
Positive Control: Cyclophosphamide 
6.25      
 200 23 0.115 10.0 8 0.040 4.0 15 0.075 7.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 12 0.480 28.0 2 0.080 8.0 10 0.400 24.0 0 0.000 0.0
Trend: 1.036 1.108 0.445  
Probability: 0.150 0.134 0.328