Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01812-0011-0000-6 |
Chemical Name: | C.I. Solvent yellow 14 |
CASRN: | 842-07-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 841852 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 | 113 | 100 | 126 | 37 | 42 |
96 | 101 | 165 | 58 | ||||
95 | 98 | 111 | 39 | ||||
75 | 101 | 75 | 33 | ||||
Test Chemical | C.I. Solvent yellow 14 | 3.125 | 121r | 87 | 147 | 40 | |
138r | 97 | 201 | 48 | ||||
6.25 | 86 | 93 | 99 | 39 | 45 | ||
108 | 118 | 170 | 52 | ||||
12.5 | 79 | 59 | 116 | 49 | 49 | ||
70 | 54 | 104 | 50 | ||||
25 | 48 | 6 | 1330 | 927 | 985* | ||
37 | 6 | 1157 | 1042 | ||||
50 | |||||||
Positive Control | Methyl Methane Sulfonate | 15 | 45 | 25 | 182 | 136 | 133* |
37 | 25 | 146 | 131 | ||||
Methyl Methane Sulfonate | 250 | 82 | 124 | 223 | 90 | 85* | |
66 | 80 | 156 | 79 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 | 68 | 85 | 115 | 56 | 48 |
76 | 107 | 114 | 50 | ||||
78 | 102 | 98 | 42 | ||||
90 | 106 | 120 | 45 | ||||
Test Chemical | C.I. Solvent yellow 14 | 1 | 70 | 84 | 108 | 52 | 54 |
67 | 83 | 113 | 56 | ||||
2 | 88 | 100 | 109 | 41 | 44 | ||
77 | 87 | 109 | 47 | ||||
4 | 106 | 92 | 139 | 44 | 49 | ||
86 | 67 | 141 | 55 | ||||
8 | 88 | 80 | 141 | 54 | 46 | ||
73 | 89 | 82 | 38 | ||||
16 | 74 | 34 | 133 | 60 | 57 | ||
71 | 26 | 114 | 53 | ||||
Positive Control | Methyl Methane Sulfonate | 15 | 41 | 31 | 218 | 176 | 172* |
52 | 32 | 261 | 167 | ||||
Methyl Methane Sulfonate | 250 | 74 | 73 | 427 | 193 | 187* | |
73 | 69 | 399 | 182 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 | 52 | 81 | 126 | 81 | 63 |
61 | 104 | 107 | 58 | ||||
66 | 97 | 112 | 57 | ||||
79 | 118 | 130 | 55 | ||||
Test Chemical | C.I. Solvent yellow 14 | 1 | 75 | 119 | 164 | 73 | 61 |
82 | 109 | 123 | 50 | ||||
2 | 60 | 103 | 124 | 69 | 64 | ||
82 | 71 | 145 | 59 | ||||
4 | 52 | 33 | 141 | 91 | 105* | ||
47 | 43 | 168 | 120 | ||||
8 | 44 | 16 | 204 | 156 | 142* | ||
44 | 30 | 170 | 128 | ||||
16 | 56 | 30 | 171 | 101 | 103* | ||
58 | 31 | 181 | 105 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 7r | 2 | 326 | 1590 | 653* |
20 | 5 | 385 | 653 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 | 58 | 94 | 113 | 65 | 53 |
57 | 92 | 114 | 67 | ||||
84 | 98 | 115 | 46 | ||||
82 | 115 | 86 | 35 | ||||
Test Chemical | C.I. Solvent yellow 14 | 1 | 63 | 87 | 120 | 64 | 58 |
72 | 91 | 113 | 52 | ||||
2 | 57 | 73 | 102 | 59 | 72 | ||
60 | 72 | 152 | 85 | ||||
4 | 51 | 37 | 134 | 88 | 79 | ||
56 | 36 | 118 | 70 | ||||
8 | 24 | 11 | 143 | 199 | 175* | ||
38 | 18 | 172 | 152 | ||||
16 | 52 | 28 | 101 | 64 | 69 | ||
62 | 32 | 137 | 74 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 15 | 4 | 177 | 398 | 418* |
18 | 5 | 234 | 437 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 | 96 | 117 | 86 | 30 | 33 |
97 | 105 | 108 | 37 | ||||
90 | 88 | 73 | 27 | ||||
90 | 90 | 103 | 38 | ||||
Test Chemical | C.I. Solvent yellow 14 | 2 | 65 | 83 | 89 | 46 | 41 |
67 | 82 | 73 | 36 | ||||
4 | 64 | 52 | 107 | 55 | 49 | ||
84 | 73 | 109 | 44 | ||||
8 | 63 | 28 | 144 | 77 | 85* | ||
47 | 27 | 133 | 94 | ||||
12 | 38 | 9 | 124 | 110 | 91* | ||
39 | 13 | 86 | 73 | ||||
16 | 33 | 9 | 85 | 86 | 75* | ||
24 | 6 | 45 | 63 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 14 | 2 | 262 | 616 | 566* |
13 | 3 | 193 | 515 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 | 101 | 103 | 135 | 45 | 49 |
92 | 103 | 145 | 52 | ||||
95 | 97 | 154 | 54 | ||||
97 | 96 | 132 | 45 | ||||
Test Chemical | C.I. Solvent yellow 14 | 1 | 105 | 87 | 155 | 49 | 56 |
94 | 77 | 175 | 62 | ||||
2 | 84 | 72 | 176 | 70 | 63 | ||
96 | 70 | 163 | 57 | ||||
4 | 83 | 39 | 134 | 54 | 66 | ||
86 | 42 | 199 | 77 | ||||
8 | 68 | 16 | 178 | 87 | 79* | ||
72 | 19 | 151 | 70 | ||||
16 | 54 | 9 | 148 | 92 | 96* | ||
47 | 6 | 142 | 101 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 54 | 21 | 603 | 370 | 349* |
58 | 28 | 570 | 328 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination