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Study Information
Study Attribute Value
CEBS Accession Number: 002-01812-0012-0000-7
Chemical Name: C.I. Solvent yellow 14
CASRN: 842-07-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 114547_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 11/30/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 3.99 ± 0.449
Test Chemical C.I. Solvent yellow 14 
875         
 4 4.97 ± 0.093
  
1750         
 4 5.36 ± 0.390
  
3500         
 4 5.97 ± 0.669
Positive Control Dimethylbenzanthracene 
2.5       
 4 7.47 ± 0.408


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/31/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.12 ± 0.282
Test Chemical C.I. Solvent yellow 14 
1750         
 4 6.32 ± 0.687
  
2625         
 4 8.00 ± 1.222
  
3500         
 4 6.57 ± 0.281
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.90 ± 1.134


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed