Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01812-0012-0000-7
Chemical Name:	C.I. Solvent yellow 14
CASRN:	842-07-9
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	114547_SCE
Study Result:	Positive

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	11/30/88	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	3.99 ± 0.449
Test Chemical	C.I. Solvent yellow 14	875	4	4.97 ± 0.093
		1750	4	5.36 ± 0.390
		3500	4	5.97 ± 0.669
Positive Control	Dimethylbenzanthracene	2.5	4	7.47 ± 0.408

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	08/31/89	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	4.12 ± 0.282
Test Chemical	C.I. Solvent yellow 14	1750	4	6.32 ± 0.687
		2625	4	8.00 ± 1.222
		3500	4	6.57 ± 0.281
Positive Control	Dimethylbenzanthracene	2.5	4	8.90 ± 1.134

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed