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Study Information
Study Attribute Value
CEBS Accession Number: 002-01812-0013-0000-8
Chemical Name: C.I. Solvent yellow 14
CASRN: 842-07-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 114547_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/05/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9707
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 13.00 ± 3.36 0.0000
Test Chemical C.I. Solvent yellow 14 
875         
 8 2.75 ± 1.41 0.6608
  
1750         
 8 2.50 ± 0.33 0.7372
  
3500         
 8 1.25 ± 0.53 0.9718
Vehicle Control No Stressor 
 0         
 8 3.25 ± 1.06 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/20/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0160
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 20.75 ± 3.93 0.0000
Test Chemical C.I. Solvent yellow 14 
875         
 8 0.75 ± 0.53 0.5000
  
1750         
 8 1.00 ± 0.53 0.3521
  
3500         
 8 2.25 ± 0.59 0.0405
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/07/92 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2530
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 28.00 ± 2.42 0.0000
Test Chemical C.I. Solvent yellow 14 
875         
 8 2.50 ± 0.33 0.0962
  
1750         
 8 1.25 ± 0.53 0.5000
  
3500         
 8 2.25 ± 0.88 0.1404
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/09/93 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.6732
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 8 24.50 ± 1.72 0.0000
Test Chemical C.I. Solvent yellow 14 
875         
 8 3.00 ± 1.00 0.7215
  
1750         
 8 3.50 ± 0.73 0.5750
  
3500         
 8 3.00 ± 0.93 0.7215
Vehicle Control No Stressor 
 0         
 8 3.75 ± 0.59 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed