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Study Information
Study Attribute Value
CEBS Accession Number: 002-01815-0001-0000-8
Chemical Name: C.I. Vat yellow 4
CASRN: 128-66-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 876338_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/17/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 452 0.432 9.04 26.0 0.000
Test Chemical C.I. Vat yellow 4 
320         
 50 1046 488 0.467 9.76 26.0 8.068 
1000         
 50 1047 566 0.541 11.32 26.0 25.221 
3200         
 50 1046 653 0.624 13.06 26.0 44.607 
5000         
 50 1048 668 0.637 13.36 26.0 47.647
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 551 0.525 11.02 26.0 21.554
Mitomycin-C 
 0.005     
 10 210 328 1.562 32.80 26.0 261.795
Trend: 8.045        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/24/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 390 0.372 7.80 26.0 0.000
Test Chemical C.I. Vat yellow 4 
320         
 50 1049 496 0.473 9.92 26.0 27.179 
1000         
 50 1048 626 0.597 12.52 26.0 60.666 
3200         
 50 1049 643 0.613 12.86 26.0 64.872 
5000         
 50 1048 720 0.687 14.40 26.0 84.792
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 562 0.535 11.24 26.0 43.965
Mitomycin-C 
 0.005     
 10 210 273 1.300 27.30 26.0 249.667
Trend: 10.642        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/17/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 425 0.405 8.50 26.0 0.000
Test Chemical C.I. Vat yellow 4 
320         
 50 1050 554 0.528 11.08 26.0 30.353 
1000         
 50 1050 604 0.575 12.08 26.0 42.118 
3200         
 50 1050 611 0.582 12.22 26.0 43.765 
5000         
 50 1050 666 0.634 13.32 26.0 56.706
Positive Control Cyclophosphamide 
 0.1       
 50 1050 531 0.506 10.62 26.0 24.941
Cyclophosphamide 
 0.6       
 10 210 237 1.129 23.70 26.0 178.824
Trend: 7.071        
Probability: 0.000