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Study Information
Study Attribute Value
CEBS Accession Number: 002-01816-0001-0000-9
Chemical Name: beta-Cadinene
CASRN: 523-47-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 972780_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1   
No Activation  2  Weakly Positive 
No Activation  3  Questionable 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/19/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1042 507 0.487 10.14 25.5 0.000
Test Chemical beta-Cadinene 
8.88      
 50 1040 528 0.508 10.56 25.5 4.342
Positive Control Mitomycin-C 
 0.005     
 6 123 133 1.081 22.17 25.5 122.232
Trend: 0.000        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/04/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1021 540 0.529 10.80 25.5 0.000
Test Chemical beta-Cadinene 
15.6       
 50 1037 474 0.457 9.48 25.5 -13.577 
22.2       
 50 1021 582 0.570 11.64 30.0 7.778 
26.6       
 50 1030 665 0.646 13.30 30.0 22.072
Positive Control Mitomycin-C 
 0.005     
 25 515 563 1.093 22.52 25.5 106.697
Trend: 4.438        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 04/25/1982    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1032 566 0.548 11.32 25.5 0.000
Test Chemical beta-Cadinene 
8.9       
 50 1026 562 0.548 11.24 25.5 -0.126 
13.3       
 50 1032 594 0.576 11.88 25.5 4.947 
17.8       
 50 1039 663 0.638 13.26 29.0 16.349 
22.2       
 0 0 0 0.000 0.00 29.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 517 838 1.621 33.52 25.5 195.540
Trend: 2.791        
Probability: 0.003        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/04/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1018 661 0.649 13.22 25.5 0.000
Negative (Not Specified) 
0         
 50 1031 488 0.473 9.76 25.5 -27.103
Test Chemical beta-Cadinene 
22.2       
 50 1033 674 0.652 13.48 25.5 0.486 
26.6       
 50 1022 643 0.629 12.86 25.5 -3.104 
31.1       
 50 1020 679 0.666 13.58 25.0 2.522
Positive Control Cyclophosphamide 
1.5       
 25 517 652 1.261 26.08 25.5 94.224
Trend: 0.201        
Probability: 0.420