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Study Information
Study Attribute Value
CEBS Accession Number: 002-01817-0001-0000-0
Chemical Name: Cadmium chloride
CASRN: 10108-64-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 669323_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/28/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 484 0.469 9.68 25.5 0.000
Test Chemical Cadmium chloride 
 0.15      
 50 1042 648 0.622 12.96 35.5 32.728 
 0.175     
 50 1032 614 0.595 12.28 35.5 26.982 
 0.2       
 50 1040 644 0.619 12.88 35.5 32.162
Positive Control Mitomycin-C 
 0.001     
 50 1047 693 0.662 13.86 25.5 41.267
Mitomycin-C 
 0.01      
 5 105 219 2.086 43.80 25.5 345.153
Trend: 4.018        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/28/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 429 0.411 8.58 25.5 0.000
Test Chemical Cadmium chloride 
 0.6       
 50 1044 547 0.524 10.94 25.5 27.628 
 0.8       
 50 1042 558 0.536 11.16 25.5 30.444 
1         
 50 1038 582 0.561 11.64 25.5 36.579
Positive Control Cyclophosphamide 
 0.3       
 50 1043 575 0.551 11.50 25.5 34.290
Cyclophosphamide 
2         
 5 101 144 1.426 28.80 25.5 247.296
Trend: 4.691        
Probability: 0.000