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Study Information
Study Attribute Value
CEBS Accession Number: 002-01817-0002-0000-1
Chemical Name: Cadmium chloride
CASRN: 10108-64-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 669323_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 01/20/1983    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Cadmium chloride 
 0.25      
 50 40 0.800 50.0 13 0.260 24.0 27 0.540 34.0 0 0.000 0.0 
 0.28      
 100 65 0.650 32.0 7 0.070 7.0 58 0.580 28.0 0 0.000 0.0 
 0.3       
 10 17 1.700 60.0 4 0.400 40.0 13 1.300 50.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.65      
 50 13 0.260 20.0 10 0.200 16.0 3 0.060 6.0 0 0.000 0.0
Trend: 5.464 2.368 5.435  
Probability: 0.000 0.009 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/20/1983    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Cadmium chloride 
1.6       
 100 35 0.350 21.0 21 0.210 16.0 14 0.140 12.0 0 0.000 0.0 
1.8       
 100 70 0.700 31.0 34 0.340 24.0 35 0.350 21.0 1 0.010 1.0 
2         
 50 76 1.520 66.0 34 0.680 42.0 42 0.840 46.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 10 0.200 14.0 5 0.100 10.0 5 0.100 6.0 0 0.000 0.0
Trend: 8.371 6.190 7.179  
Probability: 0.000 0.000 0.000