Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01817-0004-0000-3
Chemical Name:	Cadmium chloride
CASRN:	10108-64-2
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	402420
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Fischer Medium	0	75	85	65	29	33
			96	121	85	30
			97	101	112	38
			61	93	62	34
Test Chemical	Cadmium chloride	0.1	72#	77	37.5	17	28
			94	95	106	38	28
		0.14	72	55	98	45	54*
			60	42	114	63	54*
		0.18	61	29	113	62	48
			86	36	88	34	48
		0.22	40	14	80	67	65*
			55	16	105	64	65*
		0.26	35	6	108	103	123*
			35#	6	150	143	123*
Positive Control	Methyl Methane Sulfonate	15	42	27	117	93	126*
Positive Control			34	22	163	159	126*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Fischer Medium	0	95	102	110	39	45
			78#	110	81	35
			74	88	135	61
Test Chemical	Cadmium chloride	0.16	107	94	90	28	34
			105	99	125	39	34
		0.2	91	63	170	62	49
			102	80	112	36	49
		0.24	70#	57	111	53	49
			82#	54	112.5	46	49
		0.28	88	40	241	91	96*
			81#	34	244.5	100	96*
		0.32	92	25	280	102	105*
			69#	18	222	108	105*
Positive Control	Methyl Methane Sulfonate	15	23	18	153	223	196*
Positive Control			40	25	204	169	196*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination