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Study Information
Study Attribute Value
CEBS Accession Number: 002-01817-0004-0000-3
Chemical Name: Cadmium chloride
CASRN: 10108-64-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 402420
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 75 85 65 29 33
    96 121 85 30
    97 101 112 38
    61 93 62 34
Test Chemical Cadmium chloride 
 0.1       
 72# 77 37.5 17 28
    94 95 106 38
  
 0.14      
 72 55 98 45 54*
    60 42 114 63
  
 0.18      
 61 29 113 62 48
    86 36 88 34
  
 0.22      
 40 14 80 67 65*
    55 16 105 64
  
 0.26      
 35 6 108 103 123*
    35# 6 150 143
Positive Control Methyl Methane Sulfonate 
15         
 42 27 117 93 126*
    34 22 163 159

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Fischer Medium 
 0         
 95 102 110 39 45
    78# 110 81 35
    74 88 135 61
Test Chemical Cadmium chloride 
 0.16      
 107 94 90 28 34
    105 99 125 39
  
 0.2       
 91 63 170 62 49
    102 80 112 36
  
 0.24      
 70# 57 111 53 49
    82# 54 112.5 46
  
 0.28      
 88 40 241 91 96*
    81# 34 244.5 100
  
 0.32      
 92 25 280 102 105*
    69# 18 222 108
Positive Control Methyl Methane Sulfonate 
15         
 23 18 153 223 196*
    40 25 204 169

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination