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Study Information
Study Attribute Value
CEBS Accession Number: 002-01820-0001-0000-4
Chemical Name: Calcium chromate
CASRN: 13765-19-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 169597_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/20/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 424 0.412 8.48 26.0 0.000
Test Chemical Calcium chromate 
 0.33      
 50 1042 604 0.580 12.08 26.0 40.812 
1         
 50 1033 803 0.777 16.06 26.0 88.837 
3.3       
 50 1036 725 0.700 14.50 26.0 70.000 
10         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1024 466 0.455 9.32 26.0 10.550
Mitomycin-C 
 0.01      
 5 105 255 2.429 51.00 26.0 489.960
Trend: 9.623        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/03/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 462 0.447 9.24 26.0 0.000
Test Chemical Calcium chromate 
 0.5       
 50 1027 580 0.565 11.60 26.0 26.275 
1         
 50 1036 714 0.689 14.28 26.0 54.098 
2.5       
 50 1042 941 0.903 18.82 26.0 101.920 
4         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.04      
 50 1034 608 0.588 12.16 26.0 31.474
Mitomycin-C 
 0.063     
 5 102 211 2.069 42.20 26.0 362.531
Trend: 13.424        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/20/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 428 0.414 8.56 26.0 0.000
Test Chemical Calcium chromate 
 0.33      
 50 1040 408 0.392 8.16 26.0 -5.131 
1         
 50 1040 477 0.459 9.54 26.0 10.913 
3.3       
 50 1038 675 0.650 13.50 26.0 57.254 
10         
 50 1034 669 0.647 13.38 26.0 56.460
Positive Control Cyclophosphamide 
 0.4       
 50 1037 588 0.567 11.76 26.0 37.118
Cyclophosphamide 
2         
 5 102 174 1.706 34.80 26.0 312.521
Trend: 10.355        
Probability: 0.000