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Study Information
Study Attribute Value
CEBS Accession Number: 002-01821-0001-0000-5
Chemical Name: Calcium cyanamide
CASRN: 156-62-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 893256_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/04/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1019 382 0.375 7.64 26.0 0.000
Test Chemical Calcium cyanamide 
10         
 50 1030 408 0.396 8.16 26.0 5.666 
33         
 50 1031 457 0.443 9.14 26.0 18.241 
100         
 50 1028 446 0.434 8.92 26.0 15.732 
333         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1014 565 0.557 11.30 26.0 48.635
Mitomycin-C 
 0.01      
 5 102 161 1.578 32.20 26.0 321.053
Trend: 2.515        
Probability: 0.006        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/04/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 417 0.400 8.34 26.0 0.000
Test Chemical Calcium cyanamide 
100         
 50 1038 388 0.374 7.76 26.0 -6.506 
333         
 50 1026 471 0.459 9.42 26.0 14.821 
1000         
 50 1031 453 0.439 9.06 26.0 9.897
Positive Control Cyclophosphamide 
 0.4       
 50 1047 672 0.642 13.44 26.0 60.535
Cyclophosphamide 
2         
 5 104 169 1.625 33.80 26.0 306.445
Trend: 2.298        
Probability: 0.011