Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01821-0002-0000-6 |
Chemical Name: | Calcium cyanamide |
CASRN: | 156-62-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 893256_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 200 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Calcium cyanamide | 300 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
450 | 200 | 7 | 0.035 | 2.0 | 0 | 0.000 | 0.0 | 7 | 0.035 | 2.0 | 0 | 0.000 | 0.0 | ||
600 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 200 | 7 | 0.035 | 3.0 | 1 | 0.005 | 0.5 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.5 | 25 | 12 | 0.480 | 20.0 | 0 | 0.000 | 0.0 | 12 | 0.480 | 20.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.989 | -0.826 | 1.666 | ||||||||||||
Probability: | 0.161 | 0.796 | 0.048 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 7 | 0.035 | 2.5 | 0 | 0.000 | 0.0 | 7 | 0.035 | 2.5 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Calcium cyanamide | 500 | 200 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
750 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
1000 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 19 | 0.095 | 8.0 | 6 | 0.030 | 2.0 | 13 | 0.065 | 6.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 15 | 0.600 | 32.0 | 5 | 0.200 | 16.0 | 10 | 0.400 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | -1.240 | 1.280 | -1.662 | ||||||||||||
Probability: | 0.893 | 0.100 | 0.952 |