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Study Information
Study Attribute Value
CEBS Accession Number: 002-01824-0001-0000-8
Chemical Name: Caprolactam
CASRN: 105-60-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 641268_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/08/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 376 0.359 7.52 26.0 -1.005
Dimethyl Sulfoxide 
0         
 50 1041 378 0.363 7.56 26.0 0.000
Test Chemical Caprolactam 
16         
 50 1045 415 0.397 8.30 26.0 9.368 
50         
 50 1040 429 0.413 8.58 26.0 13.601 
160         
 50 1050 424 0.404 8.48 26.0 11.208 
500         
 50 1050 422 0.402 8.44 26.0 10.683 
1600         
 50 1046 415 0.397 8.30 26.0 9.264 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1040 2553 2.455 51.06 26.0 576.046
Trend: 1.062        
Probability: 0.144        

Trial #: 2    Activation: No Activation    Date: 12/18/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 371 0.356 7.42 26.0 -10.119
Dimethyl Sulfoxide 
0         
 50 1036 410 0.396 8.20 26.0 0.000
Test Chemical Caprolactam 
1000         
 50 1031 426 0.413 8.52 26.0 4.406 
2000         
 50 1029 484 0.470 9.68 26.0 18.852 
3000         
 50 1046 415 0.397 8.30 50.0 0.252 
3000         
 50 1037 467 0.450 9.34 34.0 13.793 
4000         
 0 0 0 0.000 0.00 34.0 N/A 
4000         
 0 0 0 0.000 0.00 50.0 N/A 
5000         
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Mitomycin-C 
 0.01      
 50 1040 2322 2.233 46.44 26.0 464.163
Trend: 1.374        
Probability: 0.085        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/08/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 420 0.403 8.40 26.0 0.000
Negative (Not Specified) 
0         
 50 1041 425 0.408 8.50 26.0 1.190
Test Chemical Caprolactam 
50         
 50 1044 407 0.390 8.14 26.0 -3.374 
160         
 50 1048 434 0.414 8.68 26.0 2.643 
500         
 50 1049 420 0.400 8.40 26.0 -0.763 
1600         
 50 1046 424 0.405 8.48 26.0 0.470 
5000         
 50 1048 422 0.403 8.44 26.0 -0.195
Positive Control Cyclophosphamide 
1.5       
 50 1040 1232 1.185 24.64 26.0 193.615
Trend: 0.177        
Probability: 0.430        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/18/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 424 0.405 8.48 26.0 3.679
Dimethyl Sulfoxide 
0         
 50 1041 407 0.391 8.14 26.0 0.000
Test Chemical Caprolactam 
2000         
 50 1049 429 0.409 8.58 26.0 4.602 
3000         
 50 1040 432 0.415 8.64 26.0 6.245 
4000         
 50 1037 414 0.399 8.28 26.0 2.112 
5000         
 50 1036 430 0.415 8.60 26.0 6.161
Positive Control Cyclophosphamide 
2         
 50 1050 1929 1.837 38.58 26.0 369.893
Trend: 0.616        
Probability: 0.269