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Study Information
Study Attribute Value
CEBS Accession Number: 002-01827-0001-0000-1
Chemical Name: Captan
CASRN: 133-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 985028_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 10/01/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 411 0.392 8.22 26.5 0.000
Test Chemical Captan 
 0.05      
 50 1048 452 0.431 9.04 26.5 9.976 
 0.16      
 50 1049 518 0.494 10.36 26.5 25.914 
 0.5       
 50 1047 614 0.586 12.28 26.5 49.534 
1.6       
 50 1049 745 0.710 14.90 26.5 81.092
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 524 0.500 10.48 26.5 27.494
Mitomycin-C 
 0.005     
 10 210 320 1.524 32.00 26.5 288.553
Trend: 11.203        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/12/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 395 0.376 7.90 26.0 0.000
Test Chemical Captan 
 0.3       
 50 1049 578 0.551 11.56 26.0 46.469 
1         
 50 1050 586 0.558 11.72 26.0 48.354 
1.6       
 50 1049 789 0.752 15.78 26.0 99.937 
3         
 50 1048 1147 1.094 22.94 26.0 190.934
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 549 0.525 10.98 26.0 39.519
Mitomycin-C 
 0.005     
 10 210 306 1.457 30.60 26.0 287.342
Trend: 19.390        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/01/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 449 0.428 8.98 26.0 0.000
Test Chemical Captan 
 0.16      
 50 1050 464 0.442 9.28 26.0 3.242 
 0.5       
 50 1050 510 0.486 10.20 26.0 13.478 
1.6       
 50 1051 523 0.498 10.46 26.0 16.259 
5         
 50 1049 572 0.545 11.44 26.0 27.394
Positive Control Cyclophosphamide 
 0.1       
 50 1049 579 0.552 11.58 26.0 28.953
Cyclophosphamide 
 0.6       
 10 210 239 1.138 23.90 26.0 165.894
Trend: 4.290        
Probability: 0.000