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Study Information
Study Attribute Value
CEBS Accession Number: 002-01831-0001-0000-6
Chemical Name: Carbendazim
CASRN: 10605-21-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 053570_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/04/1986    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 474 0.454 9.48 26.0 0.000
Test Chemical Carbendazim 
 0.05      
 50 1042 482 0.463 9.64 26.0 1.981 
 0.16      
 50 1044 416 0.398 8.32 26.0 -12.152 
 0.5       
 50 1035 400 0.386 8.00 26.0 -14.796 
1.6       
 50 1034 422 0.408 8.44 26.0 -10.023 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 565 0.539 11.30 26.0 18.744
Mitomycin-C 
 0.005     
 10 211 266 1.261 26.60 26.0 177.931
Trend: -2.625        
Probability: 0.996        

Trial #: 2    Activation: No Activation    Date: 06/02/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 402 0.383 8.04 26.0 0.000
Test Chemical Carbendazim 
 0.05      
 50 1059 422 0.398 8.44 26.0 4.083 
 0.16      
 50 1051 425 0.404 8.50 26.0 5.621 
 0.5       
 50 1051 427 0.406 8.54 26.0 6.118 
1.6       
 50 1049 469 0.447 9.38 26.0 16.778 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 503 0.479 10.06 26.0 25.124
Mitomycin-C 
 0.005     
 10 210 295 1.405 29.50 26.0 266.915
Trend: 2.187        
Probability: 0.014        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/01/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 489 0.467 9.78 26.0 0.000
Test Chemical Carbendazim 
1.6       
 50 1048 538 0.513 10.76 26.0 9.915 
5         
 50 1044 532 0.510 10.64 26.0 9.106 
16         
 50 1052 484 0.460 9.68 26.0 -1.493 
50         
 50 1048 499 0.476 9.98 26.0 1.948 
100         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1046 583 0.557 11.66 26.0 19.337
Cyclophosphamide 
 0.6       
 10 210 238 1.133 23.80 26.0 142.658
Trend: -0.560        
Probability: 0.712        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/02/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 468 0.446 9.36 26.0 0.000
Test Chemical Carbendazim 
5         
 50 1051 474 0.451 9.48 26.0 1.089 
16         
 50 1050 517 0.492 10.34 26.0 10.365 
50         
 50 1049 479 0.457 9.58 26.0 2.350 
100         
 50 1051 540 0.514 10.80 26.0 15.165
Positive Control Cyclophosphamide 
 0.1       
 50 1049 563 0.537 11.26 26.0 20.299
Cyclophosphamide 
 0.6       
 10 210 227 1.081 22.70 26.0 142.290
Trend: 2.015        
Probability: 0.022