Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01831-0002-0000-7 |
Chemical Name: | Carbendazim |
CASRN: | 10605-21-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 053570_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Carbendazim | 50 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
100 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
160 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 45 | 0.225 | 21.0 | 15 | 0.075 | 7.5 | 30 | 0.150 | 13.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 38 | 0.760 | 44.0 | 16 | 0.320 | 24.0 | 22 | 0.440 | 34.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.584 | -1.299 | 1.304 | ||||||||||||
Probability: | 0.280 | 0.903 | 0.096 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Carbendazim | 50 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
100 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
160 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 38 | 0.190 | 17.0 | 8 | 0.040 | 3.5 | 30 | 0.150 | 14.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 24 | 0.480 | 40.0 | 8 | 0.160 | 16.0 | 16 | 0.320 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.324 | 0.000 | 0.324 | ||||||||||||
Probability: | 0.373 | 0.000 | 0.373 |