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Study Information
Study Attribute Value
CEBS Accession Number: 002-01832-0001-0000-7
Chemical Name: Carbon disulfide
CASRN: 75-15-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 635693_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/11/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1015 404 0.398 8.08 25.5 0.000
Test Chemical Carbon disulfide 
16.4       
 50 1022 401 0.392 8.02 25.5 -1.422 
54.7       
 50 1009 432 0.428 8.64 25.5 7.567 
164.2       
 50 1022 502 0.491 10.04 31.7 23.406 
547.3       
 0 0 0 0.000 0.00 31.7 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1015 525 0.517 10.50 25.5 29.950
Mitomycin-C 
 0.01      
 5 104 132 1.269 26.40 25.5 218.879
Trend: 3.425        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/25/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 515 188 0.365 7.52 25.8 0.000
Test Chemical Carbon disulfide 
165.6       
 25 514 249 0.484 9.96 25.8 32.704 
273.3       
 25 515 290 0.563 11.60 32.4 54.255 
350.4       
 25 518 297 0.573 11.88 32.4 57.064 
500.5       
 0 0 0 0.000 0.00 32.4 N/A
Positive Control Mitomycin-C 
 0.001     
 25 515 256 0.497 10.24 25.8 36.170
Mitomycin-C 
 0.01      
 5 103 149 1.447 29.80 25.8 296.277
Trend: 5.174        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/11/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1011 412 0.408 8.24 25.5 0.000
Test Chemical Carbon disulfide 
54.7       
 50 1028 451 0.439 9.02 25.5 7.656 
164.2       
 50 1012 502 0.496 10.04 25.5 21.724 
547.3       
 50 1025 521 0.508 10.42 31.7 24.729 
1642         
 0 0 0 0.000 0.00 31.7 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1008 741 0.735 14.82 25.5 80.390
Cyclophosphamide 
2         
 5 104 218 2.096 43.60 25.5 414.372
Trend: 3.754        
Probability: 0.000