Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01832-0002-0000-8 |
Chemical Name: | Carbon disulfide |
CASRN: | 75-15-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 635693_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Carbon disulfide | 1005 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
1500 | 200 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
2000 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 70 | 0.350 | 21.0 | 30 | 0.150 | 12.0 | 40 | 0.200 | 12.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 30 | 1.200 | 56.0 | 13 | 0.520 | 44.0 | 17 | 0.680 | 32.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.361 | -0.150 | 1.770 | ||||||||||||
Probability: | 0.087 | 0.560 | 0.038 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Carbon disulfide | 1005 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
1500 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
2000 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 6.25 | 200 | 20 | 0.100 | 8.5 | 10 | 0.050 | 4.5 | 10 | 0.050 | 5.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 9 | 0.360 | 24.0 | 7 | 0.280 | 24.0 | 2 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.312 | 0.571 | 0.030 | ||||||||||||
Probability: | 0.377 | 0.284 | 0.488 |